Description

An object of class "Anno" that contains associations between Disease Ontology terms and SCOP domain superfamilies (sf). This data is prepared based on the dcGO database (see http://supfam.org/SUPERFAMILY/dcGO/).

Usage

data(SCOP.sf2DO)

Value

an object of class Anno. It has slots for "annoData", "termData" and "domainData":

• annoData: a sparse matrix of domains X terms
• termData: variables describing ontology terms (i.e. columns in annoData), including: "ID" (i.e. term ID), "Name" (i.e. term Names), "Namespace" (i.e. term Namespace), and "Distance" (i.e. term Distance to the ontology root)
• domainData: variables describing domains (i.e. rows in annoData), including: "id" for SCOP sunid, and "level" for SCOP level, "description" for SCOP description

References

Fang H and Gough J. (2013) dcGO: database of domain-centric ontologies on functions, phenotypes, diseases and more. Nucleic Acids Res, 41(Database issue):D536-44.

Examples

# load data
data(SCOP.sf2DO)
SCOP.sf2DO

An object of S4 class 'Anno'
@annoData: 219 domains, 548 terms 
@termData (InfoDataFrame)
  termNames: DOID:0014667 DOID:0050117 DOID:0080015 ... DOID:8541
    DOID:9849 (548 total)
  tvarLabels: ID Name Namespace Distance
@domainData (InfoDataFrame)
  domainNames: 46458 46579 46689 ... 161070 161084 (219 total)
  dvarLabels: id level description

# retrieve info on ontology terms
termData(SCOP.sf2DO)

An object of S4 class 'InfoDataFrame'
  rowNames: DOID:0014667 DOID:0050117 DOID:0080015 ... DOID:8541
    DOID:9849 (548 total)
  colNames: ID Name Namespace Distance

# retrieve info on SCOP domains
domainData(SCOP.sf2DO)

An object of S4 class 'InfoDataFrame'
  rowNames: 46458 46579 46689 ... 161070 161084 (219 total)
  colNames: id level description

# retrieve the first 5 rows and columns of annotation data
x <- annoData(SCOP.sf2DO)[1:5,1:5]
x

5 x 5 sparse Matrix of class "dgCMatrix"
      DOID:0060058 DOID:688 DOID:0000000 DOID:0060061 DOID:0002116
46458            .        .            .            .            .
46579            .        .            .            .            .
46689            .        .            .            .            .
46966            .        .            .            .            .
47005            .        .            .            .            .

# convert the above retrieval to the full matrix
as.matrix(x)

      DOID:0060058 DOID:688 DOID:0000000 DOID:0060061 DOID:0002116
46458            0        0            0            0            0
46579            0        0            0            0            0
46689            0        0            0            0            0
46966            0        0            0            0            0
47005            0        0            0            0            0

See also